Post-sepsis chronic muscle weakness can be prevented by pharmacological protection of mitochondria
Meagan S Kingren, Alexander R Keeble, Alyson M Galvan-Lara, Jodi M Ogle, Zoltán Ungvári, Daret K St Clair, Timothy A Butterfield, Allison M Owen, Christopher S Fry, Samir P Patel, Hiroshi Saito · 2024
Read Post-sepsis chronic muscle weakness can be prevented by pharmacological protection of mitochondria by Meagan S Kingren, Alexander R Keeble, Alyson M Galvan-Lara, Jodi M Ogle, Zoltán Ungvári, Daret K St Clair, Timothy A Butterfield, Allison M Owen, Christopher S Fry, Samir P Patel, Hiroshi Saito (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11577827.txt.
Description
Meagan Kingren and co-authors test if shielding cell power plants blocks post sepsis weakness in a 2024 paper. Sepsis, a body wide germ response, fills hospital wards. Most who live through it keep long term muscle weakness after discharge.
In aged mice, a harsh belly sepsis left lasting limb weakness. Muscle power plants, the mitochondria, showed clear harm in the weak limbs. A bred mouse line with guarded power plants kept its strength. Drug style guards gave the same shield in tests. The link from power plant harm to weakness looks causal. Guard drugs may one day spare survivors the long weak tail.
Catalog record
| CREATOR | Meagan S Kingren, Alexander R Keeble, Alyson M Galvan-Lara, Jodi M Ogle, Zoltán Ungvári, Daret K St Clair, Timothy A Butterfield, Allison M Owen, Christopher S Fry, Samir P Patel, Hiroshi Saito |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |