METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer
Xupeng Bai, Jiarui Liu, Shujie Zhou, Lingzhi Wu, Xiaojie Feng, Pumin Zhang · 2024
Read METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer by Xupeng Bai, Jiarui Liu, Shujie Zhou, Lingzhi Wu, Xiaojie Feng, Pumin Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11577812.txt.
Description
Xupeng Bai and co-authors study what keeps a hard-to-treat breast cancer in a stem-like, relapse-prone state. Their 2024 work focuses on triple-negative breast cancer, a type with strong stem-like traits. A chemical mark on RNA, guided by a set of proteins, shapes how cells behave.
Data from patient cohorts show the mark is low in one stem-like subtype, due to loss of one key protein. Low marks lift levels of a growth-linked protein by blocking its decay, which keeps the stem-like state alive. Loss of that key protein traces to a second protein that strips a mark from its gene switch. The authors propose this chain as a drug target to cut relapse risk.
Catalog record
| CREATOR | Xupeng Bai, Jiarui Liu, Shujie Zhou, Lingzhi Wu, Xiaojie Feng, Pumin Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |