Microenvironment-optimized gastrodin-functionalized scaffolds orchestrate asymmetric division of recruited stem cells in endogenous bone regeneration
Shilin Pan, Yao Li, Lu Wang, Yingchao Guan, Kaiyang Xv, Qing Li, Guangli Feng, Yingrui Hu, Xiaoqian Lan, Shiyi Qin, Li Gui, Limei Li · 2024
Read Microenvironment-optimized gastrodin-functionalized scaffolds orchestrate asymmetric division of recruited stem cells in endogenous bone regeneration by Shilin Pan, Yao Li, Lu Wang, Yingchao Guan, Kaiyang Xv, Qing Li, Guangli Feng, Yingrui Hu, Xiaoqian Lan, Shiyi Qin, Li Gui, Limei Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11577785.txt.
Description
Shilin Pan and co-authors engineer a bone scaffold that steers stem cell division in a 2024 study. Weak, osteoporotic bone heals poorly because inflammation blunts stem cell function. Their scaffold blends polyurethane with a mineral phase and releases gastrodin, a plant compound, in a staged pattern.
In rats with large thigh bone defects, the best blend drove strong new bone growth. It calmed inflammation toward a healing mode and drew host stem cells to the defect. Some recruited cells divided unevenly: one daughter kept stem traits while the other committed to bone. Uneven placement of two signal proteins inside dividing cells set that split. Nearby bone loss also slowed, which hints at wider protection.
Catalog record
| CREATOR | Shilin Pan, Yao Li, Lu Wang, Yingchao Guan, Kaiyang Xv, Qing Li, Guangli Feng, Yingrui Hu, Xiaoqian Lan, Shiyi Qin, Li Gui, Limei Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |