GRAF1 deficiency leads to defective brown adipose tissue differentiation and thermogenic response
Xue Bai, Qiang Zhu, Matthew Combs, Martin Wabitsch, Christopher P Mack, Joan M Taylor · 2024
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Description
Xue Bai and co-authors pin a gene switch as a driver of brown fat growth in a 2024 study. Brown fat burns energy as heat, unlike white fat, which stores it. A pathway that steers fat cell fate was known, but its depot-level controls were not.
The switch, GRAF1, is rich in active tissues and rises as brown fat cells mature. Mice lacking it, in all tissues or just in fat, grew poor brown fat. They also failed to make heat well in the cold. Human brown fat starter cells with the same flaw healed when a drug blocked the pathway's next step. The work names a lever that might one day be tuned against metabolic disease.
Catalog record
| CREATOR | Xue Bai, Qiang Zhu, Matthew Combs, Martin Wabitsch, Christopher P Mack, Joan M Taylor |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |