Staphylococcus aureus can use an alternative pathway to be internalized by osteoblasts in absence of β1 integrins
Léo-Paul Tricou, William Mouton, Andréa Cara, Sophie Trouillet-Assant, Daniel Bouvard, Frédéric Laurent, Alan Diot, Jérôme Josse · 2024
Read Staphylococcus aureus can use an alternative pathway to be internalized by osteoblasts in absence of β1 integrins by Léo-Paul Tricou, William Mouton, Andréa Cara, Sophie Trouillet-Assant, Daniel Bouvard, Frédéric Laurent, Alan Diot, Jérôme Josse (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11576967.txt.
Description
Léo-Paul Tricou and seven colleagues study how the germ Staphylococcus aureus gets inside bone cells, in a twenty twenty-four paper. The germ's usual door uses a bridge of proteins that ends at docking spots called beta-1 integrins. A membrane protein, caveolin-1, was known to slow entry in skin cells. The team asked what happens in bone cells when the usual door is missing.
Entry needed recycling of the docking spots plus three helper switches. To their surprise, germs still entered cells that lacked the usual door, as long as caveolin-1 was also gone. Backup docking spots then took over the bridge role. The work shows the cell's membrane order decides which door the germ can use.
Catalog record
| CREATOR | Léo-Paul Tricou, William Mouton, Andréa Cara, Sophie Trouillet-Assant, Daniel Bouvard, Frédéric Laurent, Alan Diot, Jérôme Josse |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |