Pharmacovigilance study of famciclovir in the Food and Drug administration adverse event reporting system database
Runan Fang, Yang Zhou, Lu Han, Wenjing Chen, Ning Guan, Jianhong Li · 2024
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Description
Runan Fang and five co-authors present a 2024 safety study of the antiviral drug famciclovir, used mainly for shingles. They mined the US Food and Drug Administration adverse event database for harm reports tied to the drug. Statistical scans and Bayesian methods were used to flag signals that stand out from background noise.
From over 17 million reports, 432 cases tied to the drug were found. The most common harms were nausea, headache, changed mental state, vomiting, and dizziness, matching the drug label. The scan also flagged possible harms absent from the label, such as brain disorders, unsteady gait, low blood pressure, liver inflammation, and low blood counts. The authors offer the list as a guide for safer clinic use.
Catalog record
| CREATOR | Runan Fang, Yang Zhou, Lu Han, Wenjing Chen, Ning Guan, Jianhong Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |