First-in-human study of 99mTc-labeled fucoidan, a SPECT tracer targeting P-selectin
Reindert F Oostveen, Kang H Zheng, Yannick Kaiser, Nick S Nurmohamed, Jeffrey Kroon, Tim C de Wit, Edwin Poel, Joel Aerts, Francois Rouzet, Erik S G Stroes, Didier Letourneur, Hein J Verberne, Cédric Chauvierre, Mia R Ståhle · 2024
Read First-in-human study of 99mTc-labeled fucoidan, a SPECT tracer targeting P-selectin by Reindert F Oostveen, Kang H Zheng, Yannick Kaiser, Nick S Nurmohamed, Jeffrey Kroon, Tim C de Wit, Edwin Poel, Joel Aerts, Francois Rouzet, Erik S G Stroes, Didier Letourneur, Hein J Verberne, Cédric Chauvierre, Mia R Ståhle (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11576749.txt.
Description
Reindert Oostveen and co-authors gave a seaweed-based imaging tracer to humans for the first time in a 2024 study. The tracer uses fucoidan, a sugar chain from brown algae that grips P-selectin, a marker that appears on vessel walls and platelets when clots form. Tagged with a radioactive label, it could let scans spot fresh thrombosis early. Ten healthy volunteers received it for safety, spread, and radiation dose measurements.
No drug-related side effects appeared, and the radiation dose was modest. In the lab, the tracer bound human clots, and blocking the target cut that binding. Three patients with fresh leg vein clots were scanned; in one, the tracer lit up exactly at the clot. The authors call the profile favorable while noting the detection signal needs strengthening.
Catalog record
| CREATOR | Reindert F Oostveen, Kang H Zheng, Yannick Kaiser, Nick S Nurmohamed, Jeffrey Kroon, Tim C de Wit, Edwin Poel, Joel Aerts, Francois Rouzet, Erik S G Stroes, Didier Letourneur, Hein J Verberne, Cédric Chauvierre, Mia R Ståhle |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |