IL-37 suppresses CNS autoimmunity by increasing the frequency of Treg cells and reducing CD4 + T cell-derived IL-10 production
Reza Yazdani, Hamed Naziri, Gholamreza Azizi, Bogoljub Ciric, Mozhde Askari, Amir Moghadam Ahmadi, Jaya Aseervatham, Guang-Xian Zhang, Abdolmohamad Rostami · 2024
Read IL-37 suppresses CNS autoimmunity by increasing the frequency of Treg cells and reducing CD4 + T cell-derived IL-10 production by Reza Yazdani, Hamed Naziri, Gholamreza Azizi, Bogoljub Ciric, Mozhde Askari, Amir Moghadam Ahmadi, Jaya Aseervatham, Guang-Xian Zhang, Abdolmohamad Rostami (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11575187.txt.
Description
Reza Yazdani and co-authors test in 2024 whether a calming immune signal, called IL-37, can ease an attack on the brain and spine in mice. The model mimics multiple sclerosis, in which the immune system strips insulation from nerves. Blood levels of this signal run high in patients, yet its role in active disease was unclear.
Mice given the signal after illness began had milder disease and kept more nerve insulation. Fewer attack cells entered the brain and spine, and more calming regulator cells were present. The signal looks fit for study as a treatment that could quiet this kind of flare.
Catalog record
| CREATOR | Reza Yazdani, Hamed Naziri, Gholamreza Azizi, Bogoljub Ciric, Mozhde Askari, Amir Moghadam Ahmadi, Jaya Aseervatham, Guang-Xian Zhang, Abdolmohamad Rostami |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |