The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression
Ishani Morbia, Praveen Kumar, Aditi Lakshmi Satish, Akanksha Mudgal, Subhamoy Datta, Umashankar Singh · 2024
Read The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression by Ishani Morbia, Praveen Kumar, Aditi Lakshmi Satish, Akanksha Mudgal, Subhamoy Datta, Umashankar Singh (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11575156.txt.
Description
Ishani Morbia and co-authors show how one DNA-binding protein guards gene switches from chemical silencing, in a study published in 2024. CGGBP1 binds GC-rich DNA and helps control gene activity and methylation, the chemical marks that can switch genes off. Oddly, the protein is little more than a DNA-binding domain plus a loose tail, yet it does many jobs.
Using shortened forms of the protein, the team found that the binding domain is what limits methylation near gene promoters. Genes the protein represses have GC-rich factor-binding sites that stay unmethylated and intact. When a form lacking the domain was expressed, those promoters gained methylation and the genes quieted further. Comparing species showed this protective role grew stronger over vertebrate evolution.
Catalog record
| CREATOR | Ishani Morbia, Praveen Kumar, Aditi Lakshmi Satish, Akanksha Mudgal, Subhamoy Datta, Umashankar Singh |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |