Spatiotemporal characterization of extracellular matrix maturation in human artificial stromal-epithelial tissue substitutes
Paula Ávila-Fernández, Miguel Etayo-Escanilla, David Sánchez-Porras, Ricardo Fernández-Valadés, Fernando Campos, Ingrid Garzón, Víctor Carriel, Miguel Alaminos, Óscar Darío García-García, Jesús Chato-Astrain · 2024
Read Spatiotemporal characterization of extracellular matrix maturation in human artificial stromal-epithelial tissue substitutes by Paula Ávila-Fernández, Miguel Etayo-Escanilla, David Sánchez-Porras, Ricardo Fernández-Valadés, Fernando Campos, Ingrid Garzón, Víctor Carriel, Miguel Alaminos, Óscar Darío García-García, Jesús Chato-Astrain (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11575135.txt.
Description
Paula Avila-Fernandez and co-authors published a study in 2024 on lab-grown human tissue. They built two-layer skin-like substitutes: a deep layer with living support cells and a surface layer on top. A second design put the surface layer on a bare scaffold with no living deep cells. The team watched how the support web between cells matured over time.
The full design's surface layer matured more, gaining markers of grown skin. Its deep cells actively built web parts like collagens near the surface. The bare design's base film stayed partly formed, with fewer key parts. Both designs served as tools to study a growth signal pathway, which fired distinctly in each. The authors say contact between the layers drives proper web growth.
Catalog record
| CREATOR | Paula Ávila-Fernández, Miguel Etayo-Escanilla, David Sánchez-Porras, Ricardo Fernández-Valadés, Fernando Campos, Ingrid Garzón, Víctor Carriel, Miguel Alaminos, Óscar Darío García-García, Jesús Chato-Astrain |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |