Formoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache
Ingrid L Peterson, Erika Liktor-Busa, Kelly L Karlage, Sally J Young, Natalie E Scholpa, Rick G Schnellmann, Tally M Largent-Milnes · 2024
Read Formoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache by Ingrid L Peterson, Erika Liktor-Busa, Kelly L Karlage, Sally J Young, Natalie E Scholpa, Rick G Schnellmann, Tally M Largent-Milnes (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11575070.txt.
Description
An asthma drug that eases airways can also spark headache, Peterson and co-authors explore in a 2024 study. The drug, formoterol, is eyed for new uses in brain disorders, which makes its headache side effect worth a fresh look. The team studies a midbrain hub where the drug shifts the tone of the brain's own cannabis-like signals.
Those signals normally hold pain circuits in check, and their drop is tied to headache states. Headache burden falls hardest on women, and medication overuse headache is rising worldwide. Tracing how the drug moves these signals over time may reveal why headaches follow. The work could guide safer repurposing of a common inhaler drug.
Catalog record
| CREATOR | Ingrid L Peterson, Erika Liktor-Busa, Kelly L Karlage, Sally J Young, Natalie E Scholpa, Rick G Schnellmann, Tally M Largent-Milnes |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |