Non parametric differential network analysis: a tool for unveiling specific molecular signatures
Pietro Hiram Guzzi, Arkaprava Roy, Marianna Milano, Pierangelo Veltri · 2024
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Description
Pietro Guzzi and three co-authors introduce a 2024 tool for comparing gene and protein networks between groups. When the links inside these networks change, the traits of cells can change too. Standard tools look for such rewiring, but many assume data follow a bell shaped curve.
The new method drops that assumption and uses rank based links between gene pairs, plus changes in single gene levels. It also builds sex and gender into the comparison. Applied to public liver data on diabetes and artery disease, the tool found distinct networks for men and women. The authors present it as a way to surface group specific molecular patterns that other tools may miss.
Catalog record
| CREATOR | Pietro Hiram Guzzi, Arkaprava Roy, Marianna Milano, Pierangelo Veltri |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |