A semi-automatic pipeline integrating histological and µCT data in a mouse model of lung fibrosis
Elena Vincenzi, Martina Buccardi, Erica Ferrini, Alice Fantazzini, Eugenia Polverini, Gino Villetti, Nicola Sverzellati, Andrea Aliverti, Curzio Basso, Francesca Pennati, Franco Fabio Stellari · 2024
Read A semi-automatic pipeline integrating histological and µCT data in a mouse model of lung fibrosis by Elena Vincenzi, Martina Buccardi, Erica Ferrini, Alice Fantazzini, Eugenia Polverini, Gino Villetti, Nicola Sverzellati, Andrea Aliverti, Curzio Basso, Francesca Pennati, Franco Fabio Stellari (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11575023.txt.
Description
Vincenzi and colleagues present in 2024 a semi-automatic pipeline that aligns microscope sections of lung tissue with matching slices from micro-CT scans in a mouse model of lung fibrosis. The two views complement each other: scans follow disease over time, while histology shows fine damage. The tool rotates the scan volume, finds the coronal slice matching each section, and extracts density measures from it.
Matching succeeded in most cases and cut alignment time from forty minutes to five. Scan and tissue scores correlated well. The authors say the link gives drug studies a fuller, faster read on fibrosis.
Catalog record
| CREATOR | Elena Vincenzi, Martina Buccardi, Erica Ferrini, Alice Fantazzini, Eugenia Polverini, Gino Villetti, Nicola Sverzellati, Andrea Aliverti, Curzio Basso, Francesca Pennati, Franco Fabio Stellari |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |