A Method for Multimodal IVA Fusion Within a MISA Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies
Rogers F. Silva, Eswar Damaraju, Xinhui Li, Peter Kochunov, Judith M. Ford, Daniel H. Mathalon, Jessica A. Turner, Theo G. M. van Erp, Tulay Adali, Vince D. Calhoun · 2024
Read A Method for Multimodal IVA Fusion Within a MISA Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies by Rogers F. Silva, Eswar Damaraju, Xinhui Li, Peter Kochunov, Judith M. Ford, Daniel H. Mathalon, Jessica A. Turner, Theo G. M. van Erp, Tulay Adali, Vince D. Calhoun (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11574741.txt.
Description
Silva and co-authors present a method for blending several kinds of brain scans into shared patterns that reveal traits of age, sex, thinking, and schizophrenia. Large studies now collect many scan types for each person, and single-scan analysis misses links between them. A general framework exists to find sources shared across data sets, but it needed a working method for the multi-scan case.
The team applied their model to three scan types: brain structure, resting brain activity, and water flow in tissue. They ran it on two large groups, one of healthy volunteers and one including patients. Linked patterns emerged that track age, sex, and thinking scores, and differ in schizophrenia. Such shared markers may sharpen how brain disorders are studied.
Catalog record
| CREATOR | Rogers F. Silva, Eswar Damaraju, Xinhui Li, Peter Kochunov, Judith M. Ford, Daniel H. Mathalon, Jessica A. Turner, Theo G. M. van Erp, Tulay Adali, Vince D. Calhoun |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |