Restoring brain connectivity by phrenic nerve stimulation in sedated and mechanically ventilated patients
Thiago Bassi, Elizabeth Rohrs E, Melodie Parfait, Brett C Hannigan, Steven Reynolds, Julien Mayaux, Maxens Decavèle, Jose Herrero, Alexandre Demoule, Thomas Similowski, Martin Dres · 2024
Read Restoring brain connectivity by phrenic nerve stimulation in sedated and mechanically ventilated patients by Thiago Bassi, Elizabeth Rohrs E, Melodie Parfait, Brett C Hannigan, Steven Reynolds, Julien Mayaux, Maxens Decavèle, Jose Herrero, Alexandre Demoule, Thomas Similowski, Martin Dres (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11574298.txt.
Description
Thiago Bassi and co-authors test a nerve stimulation treatment in deeply sedated patients in a paper published in 2024. Patients on breathing machines under deep sedation lose the natural loop linking brain, diaphragm, and lungs. Survivors often face thinking problems afterward. The team asked whether stimulating the phrenic nerve, which drives the diaphragm, could wake the brain side of that loop.
Six patients with severe lung failure took part in a crossover study, receiving stimulation on top of machine breathing. Brain activity, connectivity, and synchrony rose across wide areas of the cortex. The pattern resembled that of natural breathing in awake people. The authors call for larger studies to test whether the effect improves patient outcomes.
Catalog record
| CREATOR | Thiago Bassi, Elizabeth Rohrs E, Melodie Parfait, Brett C Hannigan, Steven Reynolds, Julien Mayaux, Maxens Decavèle, Jose Herrero, Alexandre Demoule, Thomas Similowski, Martin Dres |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |