Developmental toxicity and mechanism of dibutyl phthalate on the development of subintestinal vessels in zebrafish
Wei Peng, Xiaokun Yi, Yuyang Peng, Huiqiang Lu, Haijin Liu · 2024
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Description
Five researchers test how a common plastic softener harms blood vessel growth in zebrafish in a paper from 2024. The chemical, dibutyl phthalate, is used in many daily products. Its effects on developing vessels were not well known. The team exposed zebrafish embryos to several doses and tracked growth, heart rate, and vessel sprouting under the gut.
Exposed fish showed higher oxidative stress and lower activity of protective enzymes. Genes tied to vessel growth rose in an abnormal pattern. A natural antioxidant and a vessel-blocking drug each partly reversed the harm. The authors conclude the chemical disrupts vessel growth through stress pathways. Zebrafish serve here as an early warning model.
Catalog record
| CREATOR | Wei Peng, Xiaokun Yi, Yuyang Peng, Huiqiang Lu, Haijin Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |