New insights into the role of the CHI3L2 protein in invasive ductal breast carcinoma
Agnieszka Rusak, Ewa Kątnik, Tomasz Górnicki, Christina Schmuttermaier, Krzysztof Kujawa, Aleksandra Piotrowska, Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Andrzej Wojnar, Piotr Dzięgiel, Julia Kzhyshkowska · 2024
Read New insights into the role of the CHI3L2 protein in invasive ductal breast carcinoma by Agnieszka Rusak, Ewa Kątnik, Tomasz Górnicki, Christina Schmuttermaier, Krzysztof Kujawa, Aleksandra Piotrowska, Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Andrzej Wojnar, Piotr Dzięgiel, Julia Kzhyshkowska (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11574116.txt.
Description
Agnieszka Rusak and co-authors study a little-known protein in breast cancer in a 2024 paper. The protein belongs to a family that can help tumors grow, spread, and build blood vessels. Its cousin is well studied, but this member's role in the most common breast cancer type stayed unclear.
The team measured the protein in seventy-four tumor samples and in cell cultures. Levels fell as tumor grade rose and when hormone receptors were absent. The protein tracked with two growth signaling pathways in a positive way. It linked negatively with macrophage crowding inside tumors, though. Both cancer cells and macrophages carried the protein. The mixed pattern suggests a complex, context-dependent role in tumor behavior.
Catalog record
| CREATOR | Agnieszka Rusak, Ewa Kątnik, Tomasz Górnicki, Christina Schmuttermaier, Krzysztof Kujawa, Aleksandra Piotrowska, Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Andrzej Wojnar, Piotr Dzięgiel, Julia Kzhyshkowska |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |