Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease
Anna Hofmann, Lisa M Häsler, Marius Lambert, Stephan A Kaeser, Susanne Gräber-Sultan, Ulrike Obermüller, Elke Kuder-Buletta, Christian la Fougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Nick C Fox, Natalie S Ryan, Henrik Zetterberg, Jorge J Llibre-Guerra, Richard J Perrin, Laura Ibanez, · 2024
Read Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease by Anna Hofmann, Lisa M Häsler, Marius Lambert, Stephan A Kaeser, Susanne Gräber-Sultan, Ulrike Obermüller, Elke Kuder-Buletta, Christian la Fougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Nick C Fox, Natalie S Ryan, Henrik Zetterberg, Jorge J Llibre-Guerra, Richard J Perrin, Laura Ibanez, (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11574007.txt.
Description
Anna Hofmann and a large international team track a protein called neurofilament light chain in families with inherited Alzheimer's disease. Their 2024 study uses matched spinal fluid and blood samples from 567 people in the Dominantly Inherited Alzheimer Network. The protein is a sign of nerve cell damage, and the team wanted to see how its levels move across the whole course of the disease.
Both fluid and blood levels rose early, telling carriers of the disease gene apart from non-carriers ten to twenty years before symptoms were expected. After symptoms began, the spinal fluid level kept climbing at a steady pace, while the blood level's rate of change leveled off. Changes in both tracked shrinkage of grey matter but not amyloid buildup. The team concludes the protein is a good early marker, while the spinal fluid form may suit trials in patients with symptoms better.
Catalog record
| CREATOR | Anna Hofmann, Lisa M Häsler, Marius Lambert, Stephan A Kaeser, Susanne Gräber-Sultan, Ulrike Obermüller, Elke Kuder-Buletta, Christian la Fougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Nick C Fox, Natalie S Ryan, Henrik Zetterberg, Jorge J Llibre-Guerra, Richard J Perrin, Laura Ibanez, |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |