TET3 regulates terminal cell differentiation at the metabolic level
Isabel Mulet, Carmen Grueso-Cortina, Mireia Cortés-Cano, Daniela Gerovska, Guangming Wu, Stefania Alexandra Iakab, Daniel Jimenez-Blasco, Andrea Curtabbi, Pablo Hernansanz-Agustín, Harmony Ketchum, Israel Manjarrés-Raza, F. Thomas Wunderlich, Juan Pedro Bolaños, Meelad M. Dawlaty, Carsten Hopf, José · 2024
Read TET3 regulates terminal cell differentiation at the metabolic level by Isabel Mulet, Carmen Grueso-Cortina, Mireia Cortés-Cano, Daniela Gerovska, Guangming Wu, Stefania Alexandra Iakab, Daniel Jimenez-Blasco, Andrea Curtabbi, Pablo Hernansanz-Agustín, Harmony Ketchum, Israel Manjarrés-Raza, F. Thomas Wunderlich, Juan Pedro Bolaños, Meelad M. Dawlaty, Carsten Hopf, José (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11573987.txt.
Description
Isabel Mulet and a large team of co-authors study a gene regulator's role in the gut lining, in a 2024 paper. The regulator, TET3, helps cells settle into their final jobs, and animals cannot develop normally without it. Where it acts in the intestine was unclear.
Reading single cells from mouse gut, the team found TET3 mostly in mature surface cells, not in stem cells. Without it, those cells drifted off their normal path and never gained a proper identity. The fault traced to the cells' power stations, which failed to assemble a key energy-making part. Chemical maps of the tissue matched the failure. Stem cells, which barely use TET3, showed no such problems. The work ties a fate regulator to the energy supply of finished cells.
Catalog record
| CREATOR | Isabel Mulet, Carmen Grueso-Cortina, Mireia Cortés-Cano, Daniela Gerovska, Guangming Wu, Stefania Alexandra Iakab, Daniel Jimenez-Blasco, Andrea Curtabbi, Pablo Hernansanz-Agustín, Harmony Ketchum, Israel Manjarrés-Raza, F. Thomas Wunderlich, Juan Pedro Bolaños, Meelad M. Dawlaty, Carsten Hopf, José |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |