YTHDF1 boosts the lactate accumulation to potentiate cervical cancer cells immune escape
Jing Xiong, Ling He, Xiaoshan Chai, Yongjing Zhang, Shujuan Sun · 2024
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Description
Jing Xiong and four colleagues published a cervical cancer study in two thousand twenty-four on how tumours hide from immune attack. Tumour cells pour out lactate, a waste acid that blunts killer T cells. A gene-reading protein called YTHDF1 seemed to drive that process.
Patients with high YTHDF1 fared worse and had fewer killer T cells in their tumours. In mixed cultures, boosting YTHDF1 raised lactate and weakened T cell killing; silencing it did the reverse. The protein stabilises the message for a lactate gate protein, letting more lactate flood out. The authors name the pathway a target for making immunotherapy work better in this cancer.
Catalog record
| CREATOR | Jing Xiong, Ling He, Xiaoshan Chai, Yongjing Zhang, Shujuan Sun |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |