Integrated single-cell analysis reveals heterogeneity and therapeutic insights in osteosarcoma
Dongan He, Xiaoqian Che, Haiming Zhang, Jiandong Guo, Lei Cai, Jian Li, Jinxi Zhang, Xin Jin, Jianfeng Wang · 2024
Read Integrated single-cell analysis reveals heterogeneity and therapeutic insights in osteosarcoma by Dongan He, Xiaoqian Che, Haiming Zhang, Jiandong Guo, Lei Cai, Jian Li, Jinxi Zhang, Xin Jin, Jianfeng Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11573940.txt.
Description
Osteosarcoma is a fierce bone cancer that spreads easily, and a 2024 study by Dongan He and co-authors maps its tumors cell by cell. Outcomes stay poor even with modern combined treatment, so the team sought finer detail on what drives the disease.
Using single-cell RNA sequencing, they found eleven distinct tumor cell groups, including bone-forming, cartilage-forming, and immune-like types. Each group carried its own gene pattern tied to growth and spread. A process that lets cells change type and move stood out as a driver of the aggressive forms. Maps of gene copy changes pointed to possible drug targets, and immune cell patterns differed across tumor types in ways tied to outcome.
Catalog record
| CREATOR | Dongan He, Xiaoqian Che, Haiming Zhang, Jiandong Guo, Lei Cai, Jian Li, Jinxi Zhang, Xin Jin, Jianfeng Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |