Chronic low-grade inflammation in patients with systemic sclerosis is associated with increased risk for arteriosclerotic cardiovascular disease
Ursula Heilmeier, Daria Feldmann, Andrew Leynes, Magdalena Seng, Ilona Jandova, Marius Keute, Florian Kollert, Reinhard Edmund Voll, Stephanie Finzel · 2024
Read Chronic low-grade inflammation in patients with systemic sclerosis is associated with increased risk for arteriosclerotic cardiovascular disease by Ursula Heilmeier, Daria Feldmann, Andrew Leynes, Magdalena Seng, Ilona Jandova, Marius Keute, Florian Kollert, Reinhard Edmund Voll, Stephanie Finzel (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11573558.txt.
Description
Heilmeier and eight colleagues link chronic inflammation to cardiovascular risk in systemic sclerosis in twenty twenty-four. Systemic sclerosis damages blood vessels and raises heart disease risk. About a quarter of patients have persistently raised C-reactive protein, a marker of inflammation. Whether that predicts atherosclerosis in this disease was unclear.
Sixty-five patients were split into inflamed and non inflamed groups by repeated protein measures. The inflamed group had worse cholesterol and triglyceride profiles. Their estimated ten year cardiovascular risk was significantly higher. Within the inflamed group, protein levels tracked with carotid artery wall thickness. Machine learning models found lipid traits best separated the two groups. The authors identify an inflammatory subtype with higher vascular burden.
Catalog record
| CREATOR | Ursula Heilmeier, Daria Feldmann, Andrew Leynes, Magdalena Seng, Ilona Jandova, Marius Keute, Florian Kollert, Reinhard Edmund Voll, Stephanie Finzel |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |