Impact of diabetes mellitus on the risk of Alzheimer’s disease: a mendelian randomization study
Weichao Wang, Jie Zhang, Man Zhang, Chengyuan Zhang, Huanli Liu, Wanlin Li, Yimeng Fan · 2024
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Description
Weichao Wang and co-authors probe, in a 2024 study, whether diabetes raises the risk of Alzheimer's disease. Past work on the link has been mixed. The team used Mendelian randomization, a genetic method that mimics a trial, comparing people who inherit markers for a trait with those who do not. That design cuts the effect of lifestyle habits.
They pulled genetic markers for six diabetic traits, eight metabolic risk factors, and seven diabetic genes from large European cohorts. High fasting insulin and high total cholesterol each tracked with higher risk of Alzheimer's disease. High blood pressure, by contrast, tracked with lower risk. Diabetes itself, of either main type, showed no clear effect, and neither did the named genes. The authors conclude that metabolic traits tied to diabetes, rather than the disease itself, may drive the risk.
Catalog record
| CREATOR | Weichao Wang, Jie Zhang, Man Zhang, Chengyuan Zhang, Huanli Liu, Wanlin Li, Yimeng Fan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |