Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells
Sanni Peltonen, Tuuli-Maria Sonninen, Jonna Niskanen, Jari Koistinaho, Marika Ruponen, Šárka Lehtonen · 2024
Read Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells by Sanni Peltonen, Tuuli-Maria Sonninen, Jonna Niskanen, Jari Koistinaho, Marika Ruponen, Šárka Lehtonen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11571670.txt.
Description
Sanni Peltonen and five co-authors grow vessel wall cells from Parkinson's patients and find the famous LRRK2 mutation stirring them into an inflamed state. Pericytes guard brain vessels and calm inflammation, yet their part in Parkinson's disease is barely studied. The team made pericyte-like cells from reprogrammed stem cells of patients carrying the G2019S mutation and of healthy donors. Gene profiles and behavior assays compared the two.
Mutant cells spoke a more inflammatory, vessel-growing dialect than healthy ones. They migrated at altered speed and, under inflammatory provocation, released more of two alarm signals. Pericytes, the authors argue, belong in the Parkinson's story.
Catalog record
| CREATOR | Sanni Peltonen, Tuuli-Maria Sonninen, Jonna Niskanen, Jari Koistinaho, Marika Ruponen, Šárka Lehtonen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |