Cancer immunogenic cell death via pyroptosis with CXCR4-targeted nanotoxins in hepatocellular carcinoma
Yingbin Huang, Yihu Li, Rui He, Shuyi Dong, Zheng Zhao, Xingyuan Jiao · 2024
Read Cancer immunogenic cell death via pyroptosis with CXCR4-targeted nanotoxins in hepatocellular carcinoma by Yingbin Huang, Yihu Li, Rui He, Shuyi Dong, Zheng Zhao, Xingyuan Jiao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11570815.txt.
Description
Yingbin Huang and co-authors build a tiny targeted toxin that kills liver cancer cells and wakes the immune system. The toxin homes to a marker found on many liver tumor cells. Once inside, it triggers pyroptosis, a fiery form of cell death that spills signals the immune system can hear. Their 2024 study tests the toxin in cells and in mice.
The toxin folds itself into round particles and entered only tumor cells that bore the marker. It set off a known death pathway and slowed tumor growth in mice, with no clear harm to healthy organs. In mice with full immune systems, the toxin reshaped the immune cells in and around tumors. The immune boost made the cure stronger than in mice with weak immunity. The authors back wider tests of the plan.
Catalog record
| CREATOR | Yingbin Huang, Yihu Li, Rui He, Shuyi Dong, Zheng Zhao, Xingyuan Jiao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |