Engineering of Saccharomyces cerevisiae as a platform strain for microbial production of sphingosine-1-phosphate
In-Seung Jang, Sung Jin Lee, Yong-Sun Bahn, Seung-Ho Baek, Byung Jo Yu · 2024
Read Engineering of Saccharomyces cerevisiae as a platform strain for microbial production of sphingosine-1-phosphate by In-Seung Jang, Sung Jin Lee, Yong-Sun Bahn, Seung-Ho Baek, Byung Jo Yu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11569612.txt.
Description
In-Seung Jang and co-authors present a 2024 study coaxing baker's yeast into making a medically prized fat molecule. Sphingosine-1-phosphate steers many cell activities in mammals and carries real therapeutic promise. Making it today means hard chemistry or extraction from blood, both costly, so the team tried fermentation instead.
They rewired the yeast genome in several strokes. Two human genes for shaping sphingolipids were inserted. Two native genes that would degrade the product or shunt it aside were deleted. The rebuilt strain, grown in fed-batch flasks, produced sphingosine-bearing lipids as intended. The work is a proof that a microbe can host this pathway. Cheaper, scalable production could widen the molecule's use in research and medicine.
Catalog record
| CREATOR | In-Seung Jang, Sung Jin Lee, Yong-Sun Bahn, Seung-Ho Baek, Byung Jo Yu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |