Photodynamic inactivation and its effects on the heterogeneity of bacterial resistance
Jennifer M. Soares, Vladislav V. Yakovlev, Kate C. Blanco, Vanderlei S. Bagnato · 2024
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Description
Jennifer Soares and co-authors test whether light-activated treatment can soften bacterial drug resistance in this 2024 study. The method, photodynamic inactivation, uses a dye that turns toxic under light. The team used curcumin as the dye against Staphylococcus aureus strains that already resisted three common antibiotics.
After five rounds of light treatment, the doses of antibiotic needed to stop the bacteria fell clearly for all three drugs tested. The spread of resistance within each population also narrowed, meaning the toughest holdouts were trimmed back. A more uniform population is easier for standard drugs to clear. The authors frame the light treatment as a helper therapy rather than a replacement: by cutting both resistance levels and their variety, it could make old antibiotics work again against stubborn infections.
Catalog record
| CREATOR | Jennifer M. Soares, Vladislav V. Yakovlev, Kate C. Blanco, Vanderlei S. Bagnato |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |