A comparison of cognitive decline in aged mice and mice treated with aftin-4
Neža Žnidaršič, Neža Grgurevič, Alenka Nemec Svete, Anže Meden, Tomaž Snoj · 2024
Read A comparison of cognitive decline in aged mice and mice treated with aftin-4 by Neža Žnidaršič, Neža Grgurevič, Alenka Nemec Svete, Anže Meden, Tomaž Snoj (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11569203.txt.
Description
Neža Žnidaršič and co-authors compare dementia models in mice in a 2024 study. No animal model captures Alzheimer's disease well, so the team tests two candidates side by side: naturally old mice, and mice given a chemical that triggers nerve degeneration. Behavior tests, blood markers, and brain checks follow.
Neither group shows behavior changes versus controls. The chemical group shows lower levels of one damage marker and no shift in the hallmark blood protein. Males show more brain star-cell damage in both models, while females carry stronger antioxidant defenses. The authors conclude neither model proves reliable, and sex matters in such work.
Catalog record
| CREATOR | Neža Žnidaršič, Neža Grgurevič, Alenka Nemec Svete, Anže Meden, Tomaž Snoj |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |