Reactivity of the 2-Methylfuran Phase I Metabolite 3-Acetylacrolein Toward DNA
Verena Schäfer, Simone Stegmüller, Hanna Becker, Elke Richling · 2024
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Description
Verena Schäfer and co-authors present a 2024 journal article on how a breakdown product of 2-methylfuran reacts with DNA. The parent compound forms during food heating and is common in coffee. In the body it converts to 3-acetylacrolein, which was already known to react with amino acids. The team asked whether it also binds DNA building blocks.
The compound formed adducts with three of the four DNA bases tested, and the team built sensitive methods to measure them. In isolated DNA from rat liver cells, adducts grew with dose and time. In whole cells dosed with either compound, no adducts appeared, which suggests strong detox handling inside cells.
Catalog record
| CREATOR | Verena Schäfer, Simone Stegmüller, Hanna Becker, Elke Richling |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |