Qinlian Hongqu Decoction Modulates FXR/TGR5/GLP-1 Pathway to Improve Insulin Resistance in NAFLD Mice: Bioinformatics and Experimental Study
Zhongyi Zhang, Yunliang He, Mei Zhao, Xin He, Zubing Zhou, Yuanyuan Yue, Tao Shen, Juncheng Liu, Gan Zhang, Yong Zhang · 2024
Read Qinlian Hongqu Decoction Modulates FXR/TGR5/GLP-1 Pathway to Improve Insulin Resistance in NAFLD Mice: Bioinformatics and Experimental Study by Zhongyi Zhang, Yunliang He, Mei Zhao, Xin He, Zubing Zhou, Yuanyuan Yue, Tao Shen, Juncheng Liu, Gan Zhang, Yong Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11561767.txt.
Description
Zhongyi Zhang and nine colleagues test a traditional Chinese herbal mix against fatty liver disease in mice. The decoction, called Qinlian Hongqu, had shown hints of easing the metabolic troubles tied to the disease. How it works was unknown, so the team combined animal tests with computer analysis.
Treated mice showed better blood fats, less liver fat, steadier blood sugar, and improved insulin response. Network analysis pointed to bile acid pathways. Lab checks then confirmed the mix acts through a signaling chain: the FXR and TGR5 receptors raise GLP-1, a gut hormone that aids insulin control. The authors present this chain as the decoction's main route of benefit.
Catalog record
| CREATOR | Zhongyi Zhang, Yunliang He, Mei Zhao, Xin He, Zubing Zhou, Yuanyuan Yue, Tao Shen, Juncheng Liu, Gan Zhang, Yong Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |