Study of Hydrolysis Kinetics and Synthesis of Single Isomer of Phosphoramidate ProTide-Acyclovir
Thitiphong Khamkhenshorngphanuch, Pitchayathida Mee-udorn, Maleeruk Utsintong, Chutima Thepparit, Nitipol Srimongkolpithak, Sewan Theeramunkong · 2024
Read Study of Hydrolysis Kinetics and Synthesis of Single Isomer of Phosphoramidate ProTide-Acyclovir by Thitiphong Khamkhenshorngphanuch, Pitchayathida Mee-udorn, Maleeruk Utsintong, Chutima Thepparit, Nitipol Srimongkolpithak, Sewan Theeramunkong (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11561759.txt.
Description
Acyclovir (ACV) is a vital treatment for herpes simplex (HSV) and varicella-zoster virus (VZV) infections that inhibit viral DNA polymerase. Phosphoramidate ProTides-ACV, a promising technology, circumvents the reliance on thymidine kinase (TK) for activation. Twelve novel single isomers of phosphoramidate ProTide-ACV were synthesized. Successful isomer separation was achieved, emphasizing the importance of single isomers in medical advancements.
Catalog record
| CREATOR | Thitiphong Khamkhenshorngphanuch, Pitchayathida Mee-udorn, Maleeruk Utsintong, Chutima Thepparit, Nitipol Srimongkolpithak, Sewan Theeramunkong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |