Effect of Hydrogen Sulfide on Sympathoinhibition in Obese Pithed Rats and Participation of K+ Channel
Carolina B. Gomez, Araceli Sánchez-López, Karla Carvajal, David Centurión · 2024
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Description
Hydrogen sulfide, best known as a toxic gas, also acts in the body as a signal that relaxes blood vessels and lowers pressure. Gomez and co-authors test how it damps the sympathetic nerves that squeeze vessels shut, in obese rats.
Rats fed a high-fat diet for twelve weeks were prepared so the nerve outflow driving blood pressure could be stimulated and measured. A sulfide donor drug, NaHS, clearly inhibited that outflow. The team then blocked different potassium channels one at a time. Only the blocker of inward-rectifier potassium channels reversed the drug's calming effect; blockers of other channel types did not. The results point to that channel as the route by which hydrogen sulfide quiets sympathetic drive in obesity.
Catalog record
| CREATOR | Carolina B. Gomez, Araceli Sánchez-López, Karla Carvajal, David Centurión |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |