WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy
Shaoqing Liu, Shiguang Yang, Min Xu, Qiang Zhou, Jialei Weng, Zhiqiu Hu, Minghao Xu, Wenxin Xu, Yong Yi, Yi Shi, Qiongzhu Dong, Mien-Chie Hung, Ning Ren, Chenhao Zhou · 2024
Read WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy by Shaoqing Liu, Shiguang Yang, Min Xu, Qiang Zhou, Jialei Weng, Zhiqiu Hu, Minghao Xu, Wenxin Xu, Yong Yi, Yi Shi, Qiongzhu Dong, Mien-Chie Hung, Ning Ren, Chenhao Zhou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11552608.txt.
Description
Shaoqing Liu and co-authors show that the gene WWOX tunes oleic acid signaling, shapes macrophage behavior, and sensitizes liver cancer to immunotherapy. Checkpoint inhibitors help some liver cancer patients but not others. A gene tied to fragile sites in the genome turns out to mark who responds.
WWOX is the most upregulated fragile site gene in patients who respond to checkpoint therapy. Tumors lacking it resist PD-1 treatment in a humanized mouse model, with more macrophages and fewer killer T cells. Tumor made oleic acid pushes macrophages into a suppressive state. Loss of WWOX boosts acid synthesis through a binding competition mechanism. Blocking the acid making enzyme SCD5 strengthens anti PD-1 therapy.
Catalog record
| CREATOR | Shaoqing Liu, Shiguang Yang, Min Xu, Qiang Zhou, Jialei Weng, Zhiqiu Hu, Minghao Xu, Wenxin Xu, Yong Yi, Yi Shi, Qiongzhu Dong, Mien-Chie Hung, Ning Ren, Chenhao Zhou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |