Angiopoietin 1 Attenuates Dysregulated Angiogenesis in the Gastrocnemius of DMD Mice
Andrew McClennan, Lisa Hoffman · 2024
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Description
Andrew McClennan and Lisa Hoffman test whether a vessel-stabilizing signal can calm the chaotic blood vessel growth inside dystrophic muscle, in a 2024 study. Duchenne muscular dystrophy destroys muscle for want of dystrophin, and chronic inflammation leaks the vessel lining. Angiopoietin 1 normally seals that lining. The team compared calf muscle from dystrophy-model mice and healthy mice, then injected the signal into one calf of a treated group.
Dystrophic muscle held more vessel-lining cells, in altered shapes and with altered gene expression, and its fibers ran smaller. After treatment, vessel cells thinned out and vessels turned rounder, while growth signal genes rose. Fiber size matched untreated muscle. The authors read the result as taming, not boosting, vessel growth, and say the therapy's effect on the muscle's microvascular niche deserves deeper study.
Catalog record
| CREATOR | Andrew McClennan, Lisa Hoffman |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |