Comprehensive Analysis and Verification of the Prognostic Significance of Cuproptosis-Related Genes in Colon Adenocarcinoma
Yixiao Gu, Chengze Li, Yinan Yan, Jingmei Ming, Yuanhua Li, Xiang Chao, Tieshan Wang, Maria Mesuraca, Maria Concetta Faniello · 2024
Read Comprehensive Analysis and Verification of the Prognostic Significance of Cuproptosis-Related Genes in Colon Adenocarcinoma by Yixiao Gu, Chengze Li, Yinan Yan, Jingmei Ming, Yuanhua Li, Xiang Chao, Tieshan Wang, Maria Mesuraca, Maria Concetta Faniello (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11546850.txt.
Description
Yixiao Gu and co-authors build a risk score for colon cancer from genes tied to a newly found form of cell death, in this 2024 study. The death process, called cuproptosis, is driven by copper. How it shapes colon adenocarcinoma, a common and deadly cancer, was poorly known.
Using tumor data from two large public databases, the team grouped patients into two subtypes by these genes. The groups differed in outlook and in the immune cells inside their tumors. Four genes carried the strongest signal and were combined into a risk score. High-score patients had more immune-suppressing cells and higher levels of immune checkpoint genes. The score also tracked how tumors might respond to immune therapy and to standard drugs. The authors add a chart that folds the score into routine clinical details to guide care for each patient.
Catalog record
| CREATOR | Yixiao Gu, Chengze Li, Yinan Yan, Jingmei Ming, Yuanhua Li, Xiang Chao, Tieshan Wang, Maria Mesuraca, Maria Concetta Faniello |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |