Ecto-NOX Disulfide-Thiol Exchanger 2 (ENOX2/tNOX) Is a Potential Prognostic Marker in Primary Malignant Melanoma and May Serve as a Therapeutic Target
Matti Böcker, Eftychia Chatziioannou, Heike Niessner, Constanze Hirn, Christian Busch, Kristian Ikenberg, Hubert Kalbacher, Rupert Handgretinger, Tobias Sinnberg · 2024
Read Ecto-NOX Disulfide-Thiol Exchanger 2 (ENOX2/tNOX) Is a Potential Prognostic Marker in Primary Malignant Melanoma and May Serve as a Therapeutic Target by Matti Böcker, Eftychia Chatziioannou, Heike Niessner, Constanze Hirn, Christian Busch, Kristian Ikenberg, Hubert Kalbacher, Rupert Handgretinger, Tobias Sinnberg (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11545956.txt.
Description
Böcker and eight co-authors test whether a growth-linked protein called ENOX2 can predict outcomes in malignant melanoma. They measured the protein in tumor tissue samples and checked gene data from a large cancer atlas. They also treated melanoma cell lines with a drug that blocks the protein.
High ENOX2 levels went with shorter survival and fewer immune cells inside tumors. Levels rose from benign moles to primary tumors to metastases, and with tumor thickness and stage. The blocking drug reduced cell survival in the lab. It also blunted a signal tied to resistance against a common melanoma drug. The authors propose ENOX2 as both a warning marker and a drug target.
Catalog record
| CREATOR | Matti Böcker, Eftychia Chatziioannou, Heike Niessner, Constanze Hirn, Christian Busch, Kristian Ikenberg, Hubert Kalbacher, Rupert Handgretinger, Tobias Sinnberg |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |