Enhancing Anti-PD-1 Immunotherapy by Targeting MDSCs via Hepatic Arterial Infusion in Breast Cancer Liver Metastases
Minhyung Kim, Colin A. Powers, Daniel T. Fisher, Amy W. Ku, Nickolay Neznanov, Alfiya F. Safina, Jianmin Wang, Avishekh Gautam, Siddharth Balachandran, Anuradha Krishnamurthy, Katerina V. Gurova, Sharon S. Evans, Andrei V. Gudkov, Joseph J. Skitzki · 2024
Read Enhancing Anti-PD-1 Immunotherapy by Targeting MDSCs via Hepatic Arterial Infusion in Breast Cancer Liver Metastases by Minhyung Kim, Colin A. Powers, Daniel T. Fisher, Amy W. Ku, Nickolay Neznanov, Alfiya F. Safina, Jianmin Wang, Avishekh Gautam, Siddharth Balachandran, Anuradha Krishnamurthy, Katerina V. Gurova, Sharon S. Evans, Andrei V. Gudkov, Joseph J. Skitzki (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11545300.txt.
Description
Breast cancer that spreads to the liver shrugs off PD-1 immunotherapy, partly because suppressor immune cells shield the tumors. Minhyung Kim and co-authors test curaxin, a drug that loosens DNA packaging and can stir anti-tumor immunity, delivered straight into the liver's artery in mice. The route packed the drug into tumors with little toxicity, beating intravenous delivery.
Treatment thinned the suppressor cell population while sparing the killer T cells, and adding PD-1 blockade extended survival in the breast cancer model, though not in a colon cancer one. The pairing, the team argues, deserves a path toward patients whose liver metastases resist standard immunotherapy.
Catalog record
| CREATOR | Minhyung Kim, Colin A. Powers, Daniel T. Fisher, Amy W. Ku, Nickolay Neznanov, Alfiya F. Safina, Jianmin Wang, Avishekh Gautam, Siddharth Balachandran, Anuradha Krishnamurthy, Katerina V. Gurova, Sharon S. Evans, Andrei V. Gudkov, Joseph J. Skitzki |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |