Identification of Potential Biomarkers in Papillary Thyroid Carcinoma Based on Proteomics
Yu Sun, Jiaxuan Sun, Xiaona Gao, Tiefeng Shi, Maoqing Wang · 2024
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Description
Yu Sun and co-authors search for protein markers of papillary thyroid carcinoma, the most common thyroid cancer. The study draws on five patients, comparing cancer tissue with nearby normal thyroid tissue from each. A tagging method called TMT proteomics measures thousands of proteins at once. The team then flags proteins whose levels differ between the paired tissues and annotates what they do.
In total, 639 proteins differ: 278 run higher in cancer and 361 run lower. Six of the higher proteins stand out as potential specific markers for this cancer. The authors argue these proteins and their pathways may reveal how the disease develops. The findings offer candidate markers for later validation in larger patient groups.
Catalog record
| CREATOR | Yu Sun, Jiaxuan Sun, Xiaona Gao, Tiefeng Shi, Maoqing Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |