Antiviral immunity within neural stem cells distinguishes Enterovirus-D68 strain differences in forebrain organoids
Christine Vazquez, Seble G Negatu, Carl D Bannerman, Sowmya Sriram, Guo-Li Ming, Kellie A Jurado · 2024
Read Antiviral immunity within neural stem cells distinguishes Enterovirus-D68 strain differences in forebrain organoids by Christine Vazquez, Seble G Negatu, Carl D Bannerman, Sowmya Sriram, Guo-Li Ming, Kellie A Jurado (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11539839.txt.
Description
Christine Vazquez and five co-authors watch a virus fight brain stem cells inside lab-grown mini-brains in a 2024 study. Enterovirus D68 can, in rare cases, attack the nervous system. The stem cells that build the forebrain carry their own antiviral armor, switched partly on even before attack.
Organoids grown at two stages showed those cells primed with defense genes. A brain-attacking strain of the virus, though, could block the alarm and blunt the interferon response. Milder strains could not. The contrast explains, at the level of single cell types, why some viral cousins invade the brain and others stop at the airway.
Catalog record
| CREATOR | Christine Vazquez, Seble G Negatu, Carl D Bannerman, Sowmya Sriram, Guo-Li Ming, Kellie A Jurado |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |