ΔNp63α promotes radioresistance in esophageal squamous cell carcinoma through the PLEC-KEAP1-NRF2 feedback loop
Jin Tao, Mian Mao, Yuhai Lu, Liyuan Deng, Shuhan Yu, Xiaofei Zeng, Weikun Jia, Zhiqiang Wu, Chenghua Li, Ruidong Ma, Hu Chen · 2024
Read ΔNp63α promotes radioresistance in esophageal squamous cell carcinoma through the PLEC-KEAP1-NRF2 feedback loop by Jin Tao, Mian Mao, Yuhai Lu, Liyuan Deng, Shuhan Yu, Xiaofei Zeng, Weikun Jia, Zhiqiang Wu, Chenghua Li, Ruidong Ma, Hu Chen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11538512.txt.
Description
Tao and co-authors find a loop that lets esophageal cancer resist radiation. The cancer is harsh and often shrugs off standard care in China. A p63 form called deltaNp63alpha runs high in these tumors. High levels tied to low reactive oxygen and radiation survival. The protein switches on the PLEC gene directly.
PLEC steals KEAP1, which frees the guard protein NRF2. Free NRF2 enters the nucleus and clears reactive oxygen. Radiation itself then boosts the p63 form through NRF2. Blocking NRF2 restored radiation kill in mice. The authors name NRF2 as a drug target for this cancer.
Catalog record
| CREATOR | Jin Tao, Mian Mao, Yuhai Lu, Liyuan Deng, Shuhan Yu, Xiaofei Zeng, Weikun Jia, Zhiqiang Wu, Chenghua Li, Ruidong Ma, Hu Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |