Non-invasive, continuous oral delivery of solid levodopa-carbidopa for management of Parkinson’s disease
William L Murch, John Spiridigliozzi, Adam Heller, Ephraim Heller · 2024
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Description
Murch and co-authors engineer a mouth-held device that drips Parkinson's medicine all day in this 2024 paper. Levodopa leaves the blood fast, so tablets cause swings between stiffness and excess movement. Continuous delivery would smooth those swings, but oral dosing above 100 milligrams a day was long thought impossible.
Their system hides the drug as a semisolid paste inside a reusable dental retainer. After each meal the patient slots in a fresh one-milliliter extruder, which pushes paste onto the tongue side of the teeth. Swallowed steadily, it delivers over 1,200 milligrams a day of the 4-to-1 drug mix. A referenced 15-day trial in 16 patients showed steadier blood levels and eased symptoms.
Catalog record
| CREATOR | William L Murch, John Spiridigliozzi, Adam Heller, Ephraim Heller |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |