ZNF652 exerts a tumor suppressor role in lung cancer by transcriptionally downregulating cyclin D3
Chunfeng Xie, Xu Zhou, Jinyi Wu, Weiyi Chen, Dongxue Ren, Caiyun Zhong, Zili Meng, Ye Shi, Jianyun Zhu · 2024
Read ZNF652 exerts a tumor suppressor role in lung cancer by transcriptionally downregulating cyclin D3 by Chunfeng Xie, Xu Zhou, Jinyi Wu, Weiyi Chen, Dongxue Ren, Caiyun Zhong, Zili Meng, Ye Shi, Jianyun Zhu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11538260.txt.
Description
Chunfeng Xie and eight co-authors uncover a brake on lung cancer growth in a 2024 study. The brake is a zinc finger protein, ZNF652, whose faults show up in many tumors. In lung tumor tissue and cell lines, its levels were low, and patients with the lowest levels fared worst.
Raising the protein in lung cancer cells cut their growth, spread, and invasion, while lowering it sped all three. Gene scans showed the protein mainly reshapes the cell cycle and aging programs. Follow-up tests found it halts cells at the first growth gate, raises damage-linked aging, and makes a standard chemo drug kill more cells. It does so in part by switching down a cycle driver called cyclin D3. The work names a possible drug target.
Catalog record
| CREATOR | Chunfeng Xie, Xu Zhou, Jinyi Wu, Weiyi Chen, Dongxue Ren, Caiyun Zhong, Zili Meng, Ye Shi, Jianyun Zhu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |