Scaling up production of cephalosporin C by Acremonium chrysogenum W42-I in a fermenter using submerged fermentation
Asmaa A Ibrahim, Ghadir S El-Housseiny, Khaled M Aboshanab, Ansgar Stratmann, Mahmoud A Yassien, Nadia A Hassouna · 2024
Read Scaling up production of cephalosporin C by Acremonium chrysogenum W42-I in a fermenter using submerged fermentation by Asmaa A Ibrahim, Ghadir S El-Housseiny, Khaled M Aboshanab, Ansgar Stratmann, Mahmoud A Yassien, Nadia A Hassouna (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11538202.txt.
Description
Asmaa Ibrahim and five co-authors scale up production of an antibiotic in two thousand twenty-four. Cephalosporin C is made by a fungus, Acremonium chrysogenum, and feeds the widely used cephalosporin drug family. The team moved their strain from shake flasks to a laboratory fermenter.
They tuned the fermenter settings, settling on a small inoculum, set airflow, fast stirring, and an acidic controlled pH. Two measurement methods tracked the product amount. Output rose about three and a half times over the unoptimized run. Production also rose twice as fast in the first three days compared with flasks. The run yielded about one point six grams from four liters, showing fermenters beat flasks for scale.
Catalog record
| CREATOR | Asmaa A Ibrahim, Ghadir S El-Housseiny, Khaled M Aboshanab, Ansgar Stratmann, Mahmoud A Yassien, Nadia A Hassouna |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |