Association between the plasma ceramide and coronary microvascular resistance
Lanxin Feng, Xin Zhao, Jianqiao Song, Shuwen Yang, Jianping Xiang, Min Zhang, Chenchen Tu, Xiantao Song · 2024
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Description
Lanxin Feng and co-authors study whether a blood fat called ceramide tracks resistance in the heart's small vessels. Their 2024 study enrolled 225 hospital patients who had both ceramide measures and vessel imaging. Small vessel resistance was estimated from the angiogram itself, without extra wires. The value for each patient summed the three main heart arteries. The median summed value was about forty eight.
Statistical models linked ceramide levels and their ratios to that summed resistance. Adjustments were made for other risk factors. Curve fitting checked whether the link was straight or bent. A receiver curve analysis tested how well ceramide predicts high resistance. Subgroup checks looked for cases where the link changes strength. Ceramide is suspected in small vessel disease of the heart, the authors note. The study adds patient level evidence on that suspicion, in a single center sample.
Catalog record
| CREATOR | Lanxin Feng, Xin Zhao, Jianqiao Song, Shuwen Yang, Jianping Xiang, Min Zhang, Chenchen Tu, Xiantao Song |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |