Comprehensive genomic analysis and evaluation of in vivo and in vitro safety of Heyndrickxia coagulans BC99
Ying Wu, Zhiyi Wu, Yinyin Gao, Yixuan Fan, Yao Dong, Yinan Zhang, Zhonghui Gai, Shaobin Gu · 2024
Read Comprehensive genomic analysis and evaluation of in vivo and in vitro safety of Heyndrickxia coagulans BC99 by Ying Wu, Zhiyi Wu, Yinyin Gao, Yixuan Fan, Yao Dong, Yinan Zhang, Zhonghui Gai, Shaobin Gu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11535476.txt.
Description
Ying Wu and co-authors assess the safety of a probiotic strain in this 2024 study. The strain, Heyndrickxia coagulans BC99, came from the feces of a healthy infant. It is a candidate for use in functional foods and medicines.
The team sequenced its full genome and ran a battery of safety tests. The strain did not break down red blood cells and stayed sensitive to many antibiotics. It caused no harm to gut-like cells in culture and stuck to them well. More than ninety percent survived lab tests that mimic the gut. Feeding studies in mice and rats showed no ill effects, which supports its safety case.
Catalog record
| CREATOR | Ying Wu, Zhiyi Wu, Yinyin Gao, Yixuan Fan, Yao Dong, Yinan Zhang, Zhonghui Gai, Shaobin Gu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |