IFN-γ derived from activated human CD4+ T cells inhibits the replication of SARS-CoV-2 depending on cell-type and viral strain
Jun Shimizu, Tadahiro Sasaki, Guang Han Ong, Ritsuko Koketsu, Yoshihiro Samune, Emi E Nakayama, Tetsuharu Nagamoto, Yuki Yamamoto, Kazuo Miyazaki, Tatsuo Shioda · 2024
Read IFN-γ derived from activated human CD4+ T cells inhibits the replication of SARS-CoV-2 depending on cell-type and viral strain by Jun Shimizu, Tadahiro Sasaki, Guang Han Ong, Ritsuko Koketsu, Yoshihiro Samune, Emi E Nakayama, Tetsuharu Nagamoto, Yuki Yamamoto, Kazuo Miyazaki, Tatsuo Shioda (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11535250.txt.
Description
Jun Shimizu and colleagues report a laboratory study, published in 2024, on how fluid from activated human CD4 T cells affects SARS-CoV-2. The work asks what soluble mediators from those immune cells do to viral spread, and which mediator matters most.
The fluid inhibited viral propagation, but the effect depended on viral strain and host cell type. The original wild-type virus was most susceptible, while the Delta variant resisted in a human monocyte cell line. The fluid also abolished antibody-dependent enhancement for the original strain. The authors attribute most inhibition to interferon-gamma in the fluid, and they argue that new variants should be tested for sensitivity to it.
Catalog record
| CREATOR | Jun Shimizu, Tadahiro Sasaki, Guang Han Ong, Ritsuko Koketsu, Yoshihiro Samune, Emi E Nakayama, Tetsuharu Nagamoto, Yuki Yamamoto, Kazuo Miyazaki, Tatsuo Shioda |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |