GLCCI1 alleviates GRP78-initiated endoplasmic reticulum stress-induced apoptosis of retinal ganglion cells in diabetic retinopathy by upregulating and interacting with HSP90AB1
Jiayou Liu, Hongdan Yu, Shengxue Yu, Mengren Liu, Xinyuan Chen, Yufei Wang, Jing Li, Caixing Shi, Wenqiang Liu, Zhongfu Zuo, Xuezheng Liu · 2024
Read GLCCI1 alleviates GRP78-initiated endoplasmic reticulum stress-induced apoptosis of retinal ganglion cells in diabetic retinopathy by upregulating and interacting with HSP90AB1 by Jiayou Liu, Hongdan Yu, Shengxue Yu, Mengren Liu, Xinyuan Chen, Yufei Wang, Jing Li, Caixing Shi, Wenqiang Liu, Zhongfu Zuo, Xuezheng Liu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11535184.txt.
Description
Jiayou Liu and co-authors show a protective gene shields retinal ganglion cells from stress-driven death in diabetic retinopathy in a 2024 study. These nerve cells are among the first to die in the disease, and stress inside the cell's protein factory drives much of that loss.
The gene, GLCCI1, sits mainly in the ganglion cell layer and drops in diabetic retinas. Raising it cut cell death and organelle swelling under high sugar, and lowered stress death markers. Silencing it did the reverse. In diabetic mice, extra gene copies prevented retinal damage and vessel faults. The gene lifts and binds a heat-shock partner, which in turn controls the stress sensor that starts the death chain.
Catalog record
| CREATOR | Jiayou Liu, Hongdan Yu, Shengxue Yu, Mengren Liu, Xinyuan Chen, Yufei Wang, Jing Li, Caixing Shi, Wenqiang Liu, Zhongfu Zuo, Xuezheng Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |