Dephosphorylated uncarboxylated Matrix-Gla-Protein as candidate biomarker for immune-mediated vascular remodeling and prognosis in pulmonary hypertension
R Tobal, J Potjewijd, F de Vries, D PC van Doorn, A Jaminon, R Bittner, C Akbulut, V van Empel, P Heeringa, J Damoiseaux, L Schurgers, P van Paassen · 2024
Read Dephosphorylated uncarboxylated Matrix-Gla-Protein as candidate biomarker for immune-mediated vascular remodeling and prognosis in pulmonary hypertension by R Tobal, J Potjewijd, F de Vries, D PC van Doorn, A Jaminon, R Bittner, C Akbulut, V van Empel, P Heeringa, J Damoiseaux, L Schurgers, P van Paassen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11535036.txt.
Description
Tobal, van Paassen and their co-authors test a protein marker for immune-driven vessel remodeling and prognosis in pulmonary hypertension in 2024. The marker had already linked to cardiovascular death in systemic sclerosis, a disease often tied to this lung vessel condition.
Patients with several forms of pulmonary hypertension and connective tissue disease were compared with healthy controls. Marker levels were elevated in all patient groups, and vessel cells showed more calcification, though the two did not track directly. Patients with inflammatory signs had higher marker levels and more immune checkpoint proteins in blood. High levels also linked to worse survival.
Catalog record
| CREATOR | R Tobal, J Potjewijd, F de Vries, D PC van Doorn, A Jaminon, R Bittner, C Akbulut, V van Empel, P Heeringa, J Damoiseaux, L Schurgers, P van Paassen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |