GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states
Fan Liu, Han Zhou, Xiaonong Li, Liangliang Zhou, Chungong Yu, Haicang Zhang, Dongbo Bu, Xinmiao Liang · 2024
Read GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states by Fan Liu, Han Zhou, Xiaonong Li, Liangliang Zhou, Chungong Yu, Haicang Zhang, Dongbo Bu, Xinmiao Liang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11533411.txt.
Description
Fan Liu and seven colleagues present a free database of binding pockets on human G-protein coupled receptors, in a twenty twenty-four paper. These receptors are the largest family of membrane proteins in the body and are targets for many drugs. A receptor shifts between on and off shapes, and its drug pocket shifts too. Knowing both pocket shapes helps drug design.
The database holds near 128,000 predicted pockets from more than eight hundred receptors in both states. Pockets came from known structures plus predicted ones, screened by three geometry tools. Tests on known structures showed two tools found the true drug pocket in over sixty percent of cases. Users can search, view, and compare pockets on the public website.
Catalog record
| CREATOR | Fan Liu, Han Zhou, Xiaonong Li, Liangliang Zhou, Chungong Yu, Haicang Zhang, Dongbo Bu, Xinmiao Liang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |