Protective effect of apelin-13 in lens epithelial cells via inhibiting oxidative stress-induced apoptosis
Xue Li, Chao Gu, Qiumei Hu, Liqin Wang, Ya Zhang, Ling Yu · 2024
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Description
Xue Li and co-authors test a small peptide that shields eye lens cells from damage, in a 2024 study. Oxidative stress linked to glaucoma speeds the clouding of the lens called cataract. The peptide apelin-13 was tested on human lens cells in dishes. Some cells were stressed with hydrogen peroxide, a standard damage trigger.
Treated cells survived far better than stressed cells left alone. A blocker drug was used to check that the peptide worked through its known receptor. Measures of cell death, energy membranes, and antioxidant reserves all backed the protective story. The peptide kept a key sugar-processing pathway running under stress. That pathway's failure may help drive a severe glaucoma form, the authors suggest. Eye researchers get a candidate shield to test further.
Catalog record
| CREATOR | Xue Li, Chao Gu, Qiumei Hu, Liqin Wang, Ya Zhang, Ling Yu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |